New ways to a better business

Upfront's new 5-step chromatographic Refinery Process is based on EBA technology and enables you to conduct high yield, high throughput plasma fractionation without risk of blockage; a problem that severely limits the use of the existing standard packed bed systems with this raw material.

Upfront's plasma Refinery Process is designed to capture the labile coagulation factors first to maximize their recovery in conditions where plasma pretreatment is minimal. This keeps both processing time and costs low and at the same time significantly enhances recovery of plasma proteins compared to traditional methods.

The full Refinery Process provides a multi plasma protein product range, incl.:

• Prothrombin complex
• Factor VIII
• von Willebrand factor
• Alpha-1 antitrypsin
• Immunoglobulin G
• Albumin
• Transferrin

Polishing steps, including viral reduction treatment, are incorporated in the product purification process.

Upfront's plasma Refinery Process provides your business with the opportunity to improve process efficiency and productivity and conduct plasma fractionation with increased product yields.

Contact us to learn more about how your plasma fractionation business can be improved by use of the new chromatography technologies from Upfront; from integration with existing Cohn fractionation to the complete new 5 step Refinery Process.

Expanded Bed Adsorption is perfectly suited for processing of large batch volumes of up to thousands litres of plasma. Purpose designed adsorbents deliver dedicated adsorption of plasma protein at high flow rate in easy to clean design. Moreover, the water consumption is small compared to traditional plasma fractionation methods.